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Biosynthesis of various secondary metabolites - part 1

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
1-deoxy-11-oxopentalenate + O2 + NADPH + H+ <=> pentalenolactone_D + H2O + NADP+ 1.14.13.170 pentalenolactone D synthase
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1-deoxy-11beta-hydroxypentalenic_acid + NAD+ <=> 1-deoxy-11-oxopentalenate + NADH + H+ 1.1.1.340 1-deoxy-11beta-hydroxypentalenate dehydrogenase
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(+/-)-1-deoxypentalenic_acid + 2-oxoglutarate + O2 <=> 1-deoxy-11beta-hydroxypentalenic_acid + succinate + CO2 1.14.11.35 1-deoxypentalenic acid 11beta-hydroxylase
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UDP-glucose + crocetin <=> beta-D-glucosyl_crocetin + UDP 2.4.1.271 crocetin glucosyltransferase
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UDP-glucose + beta-D-glucosyl_crocetin <=> H+ + beta-D-gentiobiosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
H+ + cannabidiolate <=> cannabidiol + CO2 not assigned
 –
cyclooctat-9-en-7-ol + O2 + reduced_acceptor <=> cyclooctat-9-ene-5,7-diol + H2O + acceptor 1.14.99.61 cyclooctat-9-en-7-ol 5-monooxygenase
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monacolin_L_acid + O2 + reduced_flavodoxin <=> monacolin_J_acid + flavin + H2O 1.14.14.125 monacolin L hydroxylase
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pentalenene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalen-13-al + H2O + oxidized_ferredoxin 1.14.15.32 pentalenene oxygenase
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geranyl_diphosphate + 2,4-dihydroxy-6-pentylbenzoate <=> cannabigerolate + diphosphate 2.5.1.102 geranyl-pyrophosphate---olivetolic acid geranyltransferase
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monacolin_J_acid + (S)-2-Methylbutanoyl-[acp] <=> lovastatin_acid + [acyl-carrier_protein] 2.3.1.238 monacolin J acid methylbutanoate transferase
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pentalenolactone_D + 2-oxoglutarate + O2 <=> pentalenolactone_F + succinate + CO2 + H2O 1.14.11.36 pentalenolactone F synthase
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cannabigerolate + O2 <=> cannabidiolate + H2O2 1.21.3.3 reticuline oxidase
1.21.3.8 cannabidiolic acid synthase
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cannabigerolate + O2 <=> DELTA9-tetrahydrocannabinolate + H2O2 1.21.3.7 tetrahydrocannabinolic acid synthase
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(3R)-3hydroxy-beta-apo-8'-carotenal + O2 <=> crocetin_dialdehyde + 3beta-hydroxy-beta-cyclocitral 1.13.11.84 crocetin dialdehyde synthase
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cyclooctat-9-ene-5,7-diol + O2 + reduced_acceptor <=> cyclooctatin + H2O + acceptor 1.14.99.62 cyclooctatin synthase
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geranylgeranyl_diphosphate <=> terpentedienyl_diphosphate 5.5.1.15 terpentedienyl-diphosphate synthase
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UDP-glucose + beta-D-gentiobiosyl_crocetin <=> beta-D-gentiobiosyl_beta-D-glucosyl_crocetin + UDP 2.4.1.271 crocetin glucosyltransferase
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picrocrocin <=> Safranal not assigned
 –
3,5,7-trioxododecanoyl-CoA <=> CoA + 2,4-dihydroxy-6-pentylbenzoate + H+ 4.4.1.26 olivetolic acid cyclase
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hexanoyl-CoA + malonyl-CoA + H+ <=> 3,5,7-trioxododecanoyl-CoA + CoA + CO2 2.3.1.206 3,5,7-trioxododecanoyl-CoA synthase
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crocetin_dialdehyde <=> crocetin not assigned
 –
(+/-)-1-deoxypentalenic_acid + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> pentalenate + oxidized_ferredoxin + H2O 1.14.15.11 pentalenic acid synthase
–
(3S)-3-hydroxycyclocitral <=> picrocrocin not assigned
 –
1-deoxy-11-oxopentalenate + O2 + NADPH + H+ <=> neopentalenolactone_D + H2O + NADP+ 1.14.13.171 neopentalenolactone D synthase
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3alpha-hydroxy-3,5-dihydromonacolin_L_acid <=> monacolin_L_acid + H2O 1.14.14.124 dihydromonacolin L hydroxylase
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UDP-glucose + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin <=> crocin + UDP + H+ 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
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Dihydromonacolin_L-[acyl-carrier_protein] + H2O <=> [acyl-carrier_protein] + dihydromonacolin_L_acid 3.1.2.31 dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
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pentalen-13-al <=> (+/-)-1-deoxypentalenic_acid not assigned
 –
pentalenolactone_F + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> pentalenolactone + H2O + oxidized_ferredoxin 1.14.19.8 pentalenolactone synthase
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dihydromonacolin_L_acid + O2 + reduced_flavodoxin <=> 3alpha-hydroxy-3,5-dihydromonacolin_L_acid + flavin + H2O 1.14.14.124 dihydromonacolin L hydroxylase
–
UDP-glucose + bis(beta-D-glucosyl)_crocetin <=> H+ + beta-D-gentiobiosyl_beta-D-glucosyl_crocetin + UDP 2.4.1.330 beta-D-glucosyl crocetin beta-1,6-glucosyltransferase
–
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + [acyl-carrier_protein] <=> Dihydromonacolin_L-[acyl-carrier_protein] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O 2.3.1.161 lovastatin nonaketide synthase
–
H+ + DELTA9-tetrahydrocannabinolate <=> DELTA9-tetrahydrocannabinol + CO2 not assigned
 –
zeaxanthin + O2 <=> (3R)-3hydroxy-beta-apo-8'-carotenal + 3beta-hydroxy-beta-cyclocitral 1.13.11.84 crocetin dialdehyde synthase
–
terpentetriene <=> terpentecin not assigned
 –
2 malonyl-CoA + [acyl-carrier_protein] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine <=> (S)-2-Methylbutanoyl-[acp] + 2 CoA + 2 CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O 2.3.1.244 2-methylbutanoate polyketide synthase
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geranylgeranyl_diphosphate + H2O <=> cyclooctat-9-en-7-ol + diphosphate 4.2.3.146 cyclooctat-9-en-7-ol synthase
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UDP-glucose + beta-D-glucosyl_crocetin <=> bis(beta-D-glucosyl)_crocetin + UDP 2.4.1.271 crocetin glucosyltransferase
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(2E,6E)-farnesyl_diphosphate <=> pentalenene + diphosphate 4.2.3.7 pentalenene synthase
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terpentedienyl_diphosphate <=> terpentetriene + diphosphate 4.2.3.36 terpentetriene synthase
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Visualization of the pathway